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The Banerjee Lab
Confocal immunofluorescence images of islets with insulin (green), and DAPI (blue) adapted from Banerjee et al. Diabetes 2016
tSNE of single-cell RNA sequencing of islets from nonpregnant and pregnant mice organized by cell type
Our group works to expand the understanding of hormonal regulation of pancreatic islets in health and disease. A major focus of the lab is elucidating the normal physiologic adaptations of islets cells, particularly insulin-producing beta-cells, during pregnancy and the postpartum periods. We hope this knowledge will reveal how defective adaptations contributes to gestational diabetes (GDM) and the future risk of type 2 diabetes in women following pregnancy.
More broadly, we anticipate that uncovering mechanisms of gestational beta-cell adaptation will identify novel therapeutic targets to expand functional beta-cell mass and new treatments for of all types of diabetes.
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